Arsenic Oxide







Product Name:   Arsenic Oxide

Formula:             As2O3

Supplier:             ESPI Metals

                           1050 Benson Way

                            Ashland, OR 97520

Telephone:         800-638-2581

Fax:                    541-488-8313

Email:                  This email address is being protected from spambots. You need JavaScript enabled to view it.

Emergency:        Infotrac 800-535-5053 (US) or 352-323-3500 (24 hour)

Recommended Uses:  Scientific Research




GHS Classification (29 CFR 1910.1200): Acute toxicity - oral, category 2, Skin corrosion/irritation, category 1B, Eye damage/irritation, category 1, Carcinogenicity, category 1A.

GHS Label Elements:

pictogramskullcrossbones     pictogramcorrosive     pictogramhealthhazard

Signal Word: Danger

Hazard Statements: H300 Fatal if swallowed, H331 Toxic if inhaled, H314 Causes severe skin burns and eye damage, H350 May cause cancer.

Precautionary Statements: P201 Obtain special instructions before use, P202 Do not handle until all safety precautions have been read and understood, P260 Do not breath dust or mists, P264 Wash skin thoroughly after handling, P270 Do not eat, drink or smoke when using this product, P271 Use only outdoors or in a well-ventilated area, P280 Wear protective gloves/protective clothing/eye protection/face protection, P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting, P303+P361+P353 IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse SKIN with water/shower, P304+P340 IF INHALED: Remove victim to fresh air and keep comfortable for breathing, P305+P351+P338 IF IN EYES: rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing, P310 Immediately call a POISON CENTER or doctor/physician, P308+P313 IF exposed or concerned: Get medical advice/attention, P363 Wash contaminated clothing before reuse, P403+P233 Store in a well-ventilated place. Keep container tightly closed, P405 Store locked up, P501 Dispose of contents/container in accordance with local, state or federal regulations.




Ingredient:     Arsenic (III) Oxide

CAS#:             1327-53-3

%:                   100

EC#:                215-481-4

Common Names and Synonyms: Arsenic trioxide, arsenous acid.




General Measures: Remove patient from area of exposure.

INHALATION: Remove to fresh air, keep warm and quiet, give oxygen if breathing is difficult. Seek immediate medical attention.

INGESTION: Quickly wipe material from mouth and rinse with water. Do not induce vomiting. Seek medical attention immediately.

SKIN: Remove contaminated clothing if necessary. Brush off any visible solids. Wash the affected area with water for at least 15 minutes. Seek medical attention. Wash contaminated clothing before reusing.

EYES: Immediately flush eyes with copious amounts of water, including under eyelids for at least 10-15 minutes. A victim may need assistance in keeping their eyelids open. Seek immediate medical attention.

Most Important Symptoms/Effects, Acute and Delayed: May cause severe irritation, vomiting, abdominal pain, diarrhea. See section 11 for more information.

Indication of Immediate Medical Attention and Special Treatment: No other relevant information available.




Extinguishing Media: Use suitable extinguishing agent for surrounding materials and type of fire.

Unsuitable Extinguishing Media: No information available.

Specific Hazards Arising from the Material: May release toxic fumes if involved in a fire.

Special Protective Equipment and Precautions for Firefighters: Wear full face, self-contained breathing apparatus and full protective clothing.




Personal Precautions, Protective Equipment, and Emergency Procedures: Wear appropriate respiratory and protective equipment specified in section 8. Isolate spill area and provide ventilation. Avoid breathing dust or fume. Avoid contact with skin and eyes. Eliminate all sources of ignition.

Methods and Materials for Containment and Cleaning Up: Avoid raising dust. Scoop or vacuum up using a vacuum system equipped with a HEPA filter. Place in properly labeled closed containers.

Environmental Precautions: Do not allow to enter drains or to be released to the environment.




Precautions for Safe Handling: Handle in an enclosed, controlled process. Avoid creating dust. Avoid breathing dust or fumes. Provide adequate ventilation if dusts are created. Avoid contact with skin and eyes. Wash thoroughly before eating or smoking. See section 8 for information on personal protection equipment.

Conditions for Safe Storage: Store in a cool, dry area. Store material tightly sealed in properly labeled containers. Protect from moisture. Do not store together with oxidizers. See section 10 for more information on incompatible materials.




Exposure Limits:                                OSHA/PEL:     ACGIH/TLV:

Arsenic, inorganic compounds (as As)     0.01 mg/m3     0.01 mg/m3

Engineering Controls: Handle in an enclosed, controlled process. Ensure adequate ventilation to maintain exposures below occupational limits. Whenever possible the use of local exhaust ventilation or other engineering controls is the preferred method of controlling exposure to airborne dust and fume to meet established occupational exposure limits. Use good housekeeping and sanitation practices. Do not use tobacco or food in work area. Wash thoroughly before eating or smoking. Do not blow dust off clothing or skin with compressed air. Clothing worn in areas of exposure to dust or fume should be restricted to the workplace and laundered regularly.

Individual Protection Measures, Such as Personal Protective Equipment:

   Respiratory Protection: NIOSH approved respirator.

   Eye Protection: Safety glasses

   Skin Protection: Impermeable gloves, protective work clothing as necessary.





Form:                  Powder or pieces

Color:                  White to gray

Odor:                   No data

Odor Threshold:  Not determined

pH:                                              N/A

Melting Point:                             312.3 oC

Boiling Point:                              No data

Flash Point:                                 N/A

Evaporation Rate:                       N/A

Flammability:                             No data

Upper Flammable Limit:             No data

Lower Flammable Limit:             No data

Vapor Pressure:                          1 mm Hg @ 212.5 oC

Vapor Density:                            N/A

Relative Density (Specific Gravity):     3.738 g/cc

Solubility in H2O:                         3.7 g/100 ml @ 20 oC

Partition Coefficient (n-octanol/water):   Not determined

Autoignition Temperature:         No data

Decomposition Temperature:     No data

Viscosity:                                     N/A




Reactivity: No specific test data available.

Chemical Stability: Stable under recommended storage conditions.

Possibility of Hazardous Reactions: May generate toxic arsine gas when in contact with acid, alkalis, or water in the presence of an active metal.

Conditions to Avoid: Avoid high temperatures, protect from water/moisture.

Incompatible Materials: Strong oxidizing agents, acids, bases, metals.

Hazardous Decomposition Products: Arsenic oxides, arsine gas.




Likely Routes of Exposure: Inhalation, skin and eyes.

Symptoms of Exposure: May cause irritation to skin and eyes and systemic poisoning with symptoms including abdominal pain, nausea, vomiting, diarrhea, and peripheral neuropathy.

Acute and Chronic Effects:

Arsenic Compounds: Arsenic compounds are mainly absorbed through the gastrointestinal tract, but some absorption may occur through intact skin or inhalation. Acute arsenic ingestion generally produces signs and symptoms within 30 minutes but symptoms may be delayed for several hours if ingested with food. Effects include vomiting, abdominal pain and diarrhea, followed by numbness and tingling of the extremities, muscle cramping, and death, in extreme cases. The first signs of long-term exposure to high levels of inorganic arsenic are usually observed in the skin, and include pigmentation changes, skin lesions, and hard patches on the palms and soles of the feet (hyperkeratosis). Cases of acute arsenical poisoning due to inhalation are exceedingly rare in industry. Increased mortality from multiple internal organ cancers (liver, kidney, lung, and bladder) and an increased incidence of skin cancer have been observed in populations consuming drinking water high in inorganic arsenic, and increased lung cancer mortality is associated with populations exposed primarily through inhalation.

Acute Toxicity: No data


Arsenic and inorganic arsenic compounds: NTP: K - Known to be carcinogenic   IARC: 1 - Carcinogenic to humans

To the best of our knowledge the chemical, physical and toxicological characteristics of the substance are not fully known.




Ecotoxicity: No data

Persistence and Degradability: No data

Bioaccumulative Potential: No data

Mobility in Soil: No data

Other Adverse Effects: Do not allow material to be released to the environment. No further relevant information available.




Waste Disposal Method:

Product: Dispose of in accordance with Federal, State and Local regulations.

Packaging: Dispose of in accordance with Federal, State and Local regulations.




UN Number:                          UN1561

UN Proper Shipping Name:   Arsenic Trioxide

Transport Hazard Class:       6.1

Packing Group:                      II

Marine Pollutant:                   No




TSCA Listed: Yes

DSL Listed: Yes

Regulation (EC) No 1272/2008 (CLP): Acute toxicity - oral, category 2, Skin corrosion/irritation, category 1B, Eye damage/irritation, category 1, Carcinogenicity, category 1A, Hazardous to the aquatic environment - acute hazard, category 1, Hazardous to the aquatic environment - chronic hazard, category 1.

WHMIS 2015 Classification: Acute toxicity, Skin corrosion/irritation, Serious eye damage/eye irritation.

HMIS Ratings: Health: 3     Flammability: 0     Physical: 0

NFPA Ratings: Health: 3     Flammability: 0     Instability: 0

Chemical Safety Assessment: A chemical safety assessment has not been carried out.




The information contained in this document is based on the state of our knowledge at the time of publication and is believed to be correct, but does not purport to be all inclusive and shall be used only as a guide. ESPI Metals makes no representation, warranty, or guarantee of any kind with respect to the information contained in this document or any use of the product based on this information. ESPI Metals shall not be held liable for any damages resulting from handling or from contact with the above product. Users should satisfy themselves that they have all current data relevant to their particular use.


Prepared by:             ESPI Metals

Revised/Reviewed:   August 2016